- Medugno L., Florio F., De Cegli R., Grosso M., Lupo A., Costanzo P. and Izzo P. “The Kruppel-like zinc-finger protein ZNF224 represses aldolase A gene transcription by interacting with the KAP-1co-repressor protein”. Gene, 359 35– 43 (2005) (27 citations).
- Lan F., Collins R, De Cegli R, Alpatov R., Horton J.R., Xiaobing Shi X., Gozani O., Cheng X. and Shi Y. “ Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression”. Nature, 448 (2007) (279 citations).
- Cesaro E., De Cegli R., Medugno L., Florio F., Grosso M., Lupo A., Izzo P. and Costanzo P. “The Kruppel-like zinc finger protein ZNF224 recuits the arginine mathyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene”. J Biol Chem, 284(47): 32321-30 (2009). Epub 2009 Sep 9 (26 citations).
- De Cegli R., Romito A., Iacobacci S., Mao L., Lauria M., Fedele A.O., Klose J., Borel C., Descombes P., Antonarakis S.E., di Bernardo D., Banfi S., Ballabio A. and Cobellis G. “A mouse Embryonic Stem Cell Bank for inducible overexpression of human Chromosome 21 genes”. Genome Biology, 11:R64 (2010) (11 citations).
- Lei Mao, Rossella De Cegli, Mario Lauria, Grit Nebrich, Jean Maurice Delabar, Yann Herault, Gilda Cobellis and Joachim Klose. Chapter 20 “Tracking the Structure of Protein Interaction Network via Multiple Genetic Perturbations on Mouse Embryonic Stem Cells — Implementation of the Entropy Maximization Principle” in the book “Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications”, ISBN 978-953-307-197-8, edited by Craig Atwood (1 citation).
- De Cegli R, Iacobacci S, Flore G, Gambardella G, Mao L, Cutillo L, Lauria M, Klose J, Illingworth E, Banfi S, di Bernardo D. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. Nucleic Acids Res. 2012 Nov 23 (10 citations).
- Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Jurgen Klisch T, Wollenberg AC, di Bernardo D, Chan L, Irazoqui JE, Ballabio A. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nature Cell Biology 2013 Apr 21 (151 citations).
- Gambardella G, Moretti MN, De Cegli R, Cardone L, Peron A, di Bernardo D.Differential Network Analysis for the identification of condition-specific pathway activity and regulation. Bioinformatics 2013 Jun 6 (21 citations).
- Giuseppina Di Fruscio, Angela Schulz, Rossella De Cegli, Marco Savarese, Margherita Mutarelli, Giancarlo Parenti, Sandro Banfi, Thomas Braulke, Vincenzo Nigro, and Andrea Ballabio. Lysoplex: An efficient toolkit to detect DNA sequence variations in the autophagy-lysosomal pathway. Autophagy. 2015;11(6):928-38. (8 citations).
- G. Di Fruscio , M. Savarese, R. De Cegli, M. Mutarelli, V. Singhmarwah, D. Di Bernardo, S. Banfi, A. Ballabio, V. Nigro . LysoPlex: a “preferential exome” strategy to clarify molecular mechanisms of autophagic vacuolar myopathies Abstracts / Neuromuscular Disorders 24 (2014) 791–924
- Alessia Calcagnì, Lotte Kors, Eric Verschuren, Rossella De Cegli, Nicolina Zampelli, Edoardo Nusco, Stefano Confalonieri, Giovanni Bertalot, Salvatore Pece, Carmine Settembre, Gabriel G. Malouf1, Jaklien C. Leemans, Emile de Heer, Marco Salvatore, Dorien J.M. Peters, Pier Paolo Di Fiore and Andrea Ballabio. Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling. Elife. 2016 Sep 26;5.
- Mansueto G, Armani A, Viscomi C, D'Orsi L, De Cegli R, Polishchuk EV, Lamperti C, Di Meo I, Romanello V, Marchet S, Saha PK, Zong H, Blaauw B, Solagna F, Tezze C, Grumati P, Bonaldo P, Pessin JE, Zeviani M, Sandri M, Ballabio A. Transcription Factor EB Controls Metabolic Flexibility during Exercise. Cell Metab. 2017 Jan 10;25(1):182-196. doi: 10.1016/j.cmet.2016.11.003. Epub 2016 Dec 20.
- Chiara Di Malta, Diletta Siciliano, Alessia Calcagni, Jlenia Monfregola, Simona Punzi, Nunzia Pastore, Andrea N. Eastes, Oliver Davis, Rossella De Cegli, Angela Zampelli, Luca G. Di Giovannantonio, Edoardo Nusco1, Nick Platt, Alessandro Guida, Margret Helga Ogmundsdottir, Luisa Lanfrancone, Rushika M. Perera, Roberto Zoncu, Pier Giuseppe Pelicci, Carmine Settembre, Andrea Ballabio. Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science 16 Jun 2017.
- Ferriero R, Nusco E, De Cegli R, Carissimo A, Manco G, Brunetti-Pierri N. Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure. J Hepatol. 2018 Aug;69(2):325-335.
- Nnah IC, Wang B, Saqcena C, Weber GF, Bonder EM, Bagley D, De Cegli R, Napolitano G, Medina DL, Ballabio A, Dobrowolski R. TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. Autophagy. 2018 Aug 27. doi: 10.1080/15548627.2018.1511504.
- Polishchuk EV, Merolla A, Lichtmannegger J, Romano A, Indrieri A, Ilyechova EY, Concilli M, De Cegli R, Crispino R, Mariniello M, Petruzzelli R, Ranucci G, Iorio R, Pietrocola F, Einer C, Borchard S, Zibert A, Schmidt HH, Di Schiavi E, Puchkova LV, Franco B, Kroemer G, Zischka H, Polishchuk RS. Activation of autophagy, observed in liver tissues from patients with Wilson disease and from Atp7b-deficient animals, protects hepatocytes from copper-induced apoptosis. Gastroenterology. 2018 Nov 16.
- Criscuolo C, Cianflone A, Lanzillo R, Carrella D, Carissimo A, Napolitano F, de Cegli R, de Candia P, La Rocca C, Petrozziello T, Matarese G, Boscia F, Secondo A, Di Bernardo D, Brescia Morra V. Glatiramer Acetate modulates ion channels expression and calcium homeostasis in B cell of patients with relapsing-remitting multiple sclerosis. Sci Rep. 2019 Mar
- Zappa F, Wilson C, Di Tullio G, Santoro M, Pucci P, Monti M, D'Amico D, Pisonero-Vaquero S, De Cegli R, Romano A, Saleem MA, Polishchuk E, Failli M, Giaquinto L, De Matteis MA. The TRAPP complex mediates secretion arrest induced by stress granule assembly. EMBO J. 2019 Oct
- De Cegli R, Iacobacci S, Fedele A, Ballabio A, di Bernardo D. A transcriptomic study of Williams-Beuren syndrome associated genes in mouse embryonic stem cells. Sci Data. 2019 Nov 6
- Marianthi Karali, Irene Guadagnino, Elena Marrocco, Rossella De Cegli, Annamaria Carissimo, Mariateresa Pizzo, Simona Casarosa, Ivan Conte, Enrico Maria Surace, Sandro Banfi. AAV-miR-204 protects from retinal degeneration by attenuation of microglia activation and photoreceptor cell death. Molecular Therapy: Nucleic Acid (2019)
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Role of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells.
Pecoraro A, Carotenuto P, Franco B, De Cegli R, Russo G, Russo A.
Int J Mol Sci. 2020 Mar 20;21(6):2143. doi: 10.3390/ijms21062143.
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Intrinsic Abnormalities of Cystic Fibrosis Airway Connective Tissue Revealed by an In Vitro 3D Stromal Model.
Mazio C, Scognamiglio LS, De Cegli R, Galietta LJV, Bernardo DD, Casale C, Urciuolo F, Imparato G, Netti PA.
Cells. 2020 Jun 1;9(6):1371. doi: 10.3390/cells9061371.
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MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C, Maddaluno M, Wanderlingh LG, Huebner AK, Cesana M, Bonn F, Polishchuk E, Hübner CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P, Settembre C.
EMBO J. 2020 Sep 1;39(17):e105696. doi: 10.15252/embj.2020105696. Epub 2020 Jul 27.
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CHOP and c-JUN up-regulate the mutant Z α1-antitrypsin, exacerbating its aggregation and liver proteotoxicity.
Attanasio S, Ferriero R, Gernoux G, De Cegli R, Carissimo A, Nusco E, Campione S, Teckman J, Mueller C, Piccolo P, Brunetti-Pierri N.
J Biol Chem. 2020 Sep 18;295(38):13213-13223. doi: 10.1074/jbc.RA120.014307. Epub 2020 Jul 28.
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GADD34 is a modulator of autophagy during starvation.
Gambardella G, Staiano L, Moretti MN, De Cegli R, Fagnocchi L, Di Tullio G, Polletti S, Braccia C, Armirotti A, Zippo A, Ballabio A, De Matteis MA, di Bernardo D.
Sci Adv. 2020 Sep 25;6(39):eabb0205. doi: 10.1126/sciadv.abb0205. Print 2020 Sep.
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Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
Piccolo P, Ferriero R, Barbato A, Attanasio S, Monti M, Perna C, Borel F, Annunziata P, Carissimo A, De Cegli R, Quagliata L, Terracciano LM, Housset C, Teckman JH, Mueller C, Brunetti-Pierri N.
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2025242118. doi: 10.1073/pnas.2025242118.
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Integrated Genomics Identifies miR-181/TFAM Pathway as a Critical Driver of Drug Resistance in Melanoma.
Barbato A, Iuliano A, Volpe M, D'Alterio R, Brillante S, Massa F, De Cegli R, Carrella S, Salati M, Russo A, Russo G, Riccardo S, Cacchiarelli D, Capone M, Madonna G, Ascierto PA, Franco B, Indrieri A, Carotenuto P.
Int J Mol Sci. 2021 Feb 11;22(4):1801. doi: 10.3390/ijms22041801.
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A gene toolbox for monitoring autophagy transcription.
Bordi M, De Cegli R, Testa B, Nixon RA, Ballabio A, Cecconi F.
Cell Death Dis. 2021 Nov 2;12(11):1044. doi: 10.1038/s41419-021-04121-9.
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TFEB Regulates ATP7B Expression to Promote Platinum Chemoresistance in Human Ovarian Cancer Cells.
Petruzzelli R, Mariniello M, De Cegli R, Catalano F, Guida F, Di Schiavi E, Polishchuk RS.
Cells. 2022 Jan 10;11(2):219. doi: 10.3390/cells11020219.
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β-catenin perturbations control differentiation programs in mouse embryonic stem cells.
Pedone E, Failli M, Gambardella G, De Cegli R, La Regina A, di Bernardo D, Marucci L.
iScience. 2022 Jan 10;25(2):103756. doi: 10.1016/j.isci.2022.103756. eCollection 2022 Feb 18.
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The differential expression of PilY1 proteins by the HsfBA phosphorelay allows twitching motility in the absence of exopolysaccharides.
Xue S, Mercier R, Guiseppi A, Kosta A, De Cegli R, Gagnot S, Mignot T, Mauriello EMF.
PLoS Genet. 2022 Apr 29;18(4):e1010188. doi: 10.1371/journal.pgen.1010188. eCollection 2022 Apr.
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TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB. Rossella De Cegli, Diego Carrella, Diletta Siciliano, Gennaro Gambardella, Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio and Diego di Bernardo. AUTOPHAGY REPORTS 2022, VOL. 1, NO. 1, 295–305 https://doi.org/10.1080/27694127.2022.2097822
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Airway surface hyperviscosity and defective mucociliary transport by IL-17/TNF-α are corrected by β-adrenergic stimulus.
Guidone D, Buccirossi M, Scudieri P, Genovese M, Sarnataro S, De Cegli R, Cresta F, Terlizzi V, Planelles G, Crambert G, Sermet I, Galietta LJ.
JCI Insight. 2022 Nov 22;7(22):e164944. doi: 10.1172/jci.insight.164944.
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Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma.
Carotenuto P, Romano A, Barbato A, Quadrano P, Brillante S, Volpe M, Ferrante L, Tammaro R, Morleo M, De Cegli R, Iuliano A, Testa M, Andreone F, Ciliberto G, Clery E, Troncone G, Palma G, Arra C, Barbieri A, Capone M, Madonna G, Ascierto PA, Lanfrancone L, Indrieri A, Franco B.
Cell Rep. 2022 Nov 8;41(6):111601. doi: 10.1016/j.celrep.2022.111601.
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Analysis of inhibitors of the anoctamin-1 chloride channel (transmembrane member 16A, TMEM16A) reveals indirect mechanisms involving alterations in calcium signalling.
Genovese M, Buccirossi M, Guidone D, De Cegli R, Sarnataro S, di Bernardo D, Galietta LJV.
Br J Pharmacol. 2023 Mar;180(6):775-785. doi: 10.1111/bph.15995. Epub 2022 Dec 18.
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EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation.
Cesana M, Tufano G, Panariello F, Zampelli N, Ambrosio S, De Cegli R, Mutarelli M, Vaccaro L, Ziller MJ, Cacchiarelli D, Medina DL, Ballabio A.
PLoS Biol. 2023 Mar 8;21(3):e3002034. doi: 10.1371/journal.pbio.3002034. eCollection 2023 Mar.
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TFEB and TFE3 drive kidney cystogenesis and tumorigenesis.
Di Malta C, Zampelli A, Granieri L, Vilardo C, De Cegli R, Cinque L, Nusco E, Pece S, Tosoni D, Sanguedolce F, Sorrentino NC, Merino MJ, Nielsen D, Srinivasan R, Ball MW, Ricketts CJ, Vocke CD, Lang M, Karim B, Lanfrancone L, Schmidt LS, Linehan WM, Ballabio A.
EMBO Mol Med. 2023 May 8;15(5):e16877. doi: 10.15252/emmm.202216877. Epub 2023 Mar 29.
- TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression.
Pasquier A, Pastore N, D'Orsi L, Colonna R, Esposito A, Maffia V, De Cegli R, Mutarelli M, Ambrosio S, Tufano G, Grimaldi A, Cesana M, Cacchiarelli D, Delalleau N, Napolitano G, Ballabio A.
EMBO J. 2023 Sep 15:e113928. doi: 10.15252/embj.2023113928.
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